He made his debut for the Colombia national football team in 2008 and has represented them 37 times, including at the 2011 Copa América and the 2014 FIFA World Cup.

Ramos returned to América de Cali for the 2008 season and was one of the key players in their 2008 Finalizacion championship, scoring in their 4–1 aggregate victory over Independiente Medellín in the finals.

[1] His first goal for Hertha came in the second round of the DFB Pokal on 22 September 2009, helping the club come back from 0–2 down to level at 2–2, only to lose in a penalty shoot-out.

[2] His first Bundesliga goal came against Stuttgart on 12 November, putting his side ahead before a late Zdravko Kuzmanović strike ensured a 1–1 draw.

On 9 April 2014, it was announced that Ramos would sign for Borussia Dortmund, joining them on 1 July 2014, moving for an undisclosed fee and penning a four-year contract with the club.

On 2 July 2011, Ramos scored the only goal of the game just before half time against Costa Rica in the group stage of the 2011 Copa América in Argentina.