Adrian Bird

Sir Adrian Peter Bird (born 3 July 1947) is a British geneticist and Buchanan Professor of Genetics at the University of Edinburgh.

Bird has spent much of his academic career in Edinburgh, from receiving his PhD in 1970 to working at the MRC Mammalian Genome Unit and later serving as director of the Wellcome Trust Centre for Cell Biology.

He helped create the Wellcome Trust Centre for Cell Biology, also in Edinburgh, and served as its director from 1999 until 2011, when he was succeeded by David Tollervey.

These are short genomic regions with a high density of CpG dinucleotides, and are commonly found in an unmethylated state within or nearby to an active gene's promoter.

Bird's group discovered that the MeCP2 protein binds specifically to methylated CpG sites, and further that disruption of this interaction causes the autism spectrum disorder Rett syndrome.

He showed convincingly that the doublet CpG is a source of mutation in vertebrates which led to the use of 'GpG' restriction enzymes to detect polymorphisms linked to genetic diseases.

[30]Bird was awarded the Gabor Medal in 1999 "in recognition of his pioneering work in the study of global mechanisms by which transcription of the mammalian genome is regulated and for his exploration into the molecular basis of fundamental biological mechanisms, particularly his development of ways of analysing methylation patterns of eukaryotic DNA using endonucleases and the discovery of and continued research into a new class of DNA sequences found in all vertebrates".

[22] In 2013, he was named a Thomson Reuters Citation Laureate and received the 2013 BBVA Foundation Frontiers of Knowledge Award in Biomedicine "for his discoveries in the field of epigenetics".