Adrian Mines (also called Adrian and De Lancey) is an unincorporated community in Jefferson County, in the U.S. state of Pennsylvania.

[1] Adrian Mines was founded around 1887 as a mining community.

The community was named for its proprietor, Adrian Iselin.

[2][3] The post office at Adrian Mines is called De Lancey.

[2] This post office has been in operation since 1888.