Known for her work with paper and fabric, she held numerous exhibitions in the Czech Republic and abroad during her lifetime including a retrospective organized by the National Gallery in Prague in 2001.

Her early work of the 1960s was exhibited at venues including the Václav Špála Gallery and the Sao Paulo biennial.

She was a founding member of the Czech art group UB 12, along with Václav Boštík, Stanislav Kolíbal, and others.

[3] After her husband's death in 1972, she shifted her artistic focus away from painting and began to use fabrics and sculptural installations.

[4] Due to the Czech Republic's political circumstances in the 1970s and 1980s, much of Šimotová's work at the time was shown on an unofficial basis or subject to censorship.