[4] She started on television in an episode of Sweet Valley High in 1996, and moved on to Saved By The Bell: The New Class, Chicken Soup for the Soul and in 2001 she had several guest appearances on Undressed.

In 2005 she had guest appearances on Charmed as Phoebe Halliwell's first disguise of the season, Eyes and was a temporary love interest of Dr. Ray Barnett on ER, and Paisley Parker on Goodnight Burbank.

Her film career includes Lakeshore Drive, (written and directed by Michael Grais and starring Wilkinson and Peter Dobson), Pomegranate, and she was the female lead in Interceptor Force 2 (AKA: Alpha Force), Missy Blue in The American Failure, and Nancy in Raze.

Wilkinson's producer credits include the films Perfection and Seconds, which showcases a woman's struggles with depression and self-injury.

Recordings of Wilkinson's vocal performance as Daughter was later used in an episode of the TV series Star Wars Rebels.

Her website hosts an annual charity auction each year which helps to support families dealing with medical expenses.