The series ended again with #529 (October 2011) prior to a company-wide revision of DC's superhero comic book line, known as "The New 52".

[3] Issue #32 (November 1938) saw the title changed again to Adventure Comics, which would remain the book's name for the duration of its existence.

In issue #12, while the series was briefly re-titled New Adventure Comics, Joe Shuster and Jerry Siegel introduced the first version of the character Jor-L as a science fiction detective in the far future; the character would eventually become the alien father of Superman, although the first Superman story, in Action Comics #1, would not appear until more than a year after Jor-L's first appearance.

Other superheroes who appeared in the early days of Adventure included Hourman (from #48 to #83); Starman created by writer Gardner Fox and artist Jack Burnley in issue #61 (April 1941)[8] (#61–102); and Joe Simon and Jack Kirby's Manhunter replacing a similarly named business-suited investigator beginning with #73 (April 1942) until #92.

[10] Starman's and Sandman's series were canceled to make room for the new features, while Genius Jones moved to the comic the new arrivals had just vacated.

[11] In issue #247 (April 1958), by Otto Binder and artist Al Plastino, Superboy met the Legion of Super-Heroes, a team of super-powered teens from the future.

[12] The group became popular, and would replace "Tales of the Bizarro World" as the Adventure backup feature with #300,[13] and soon be promoted to its lead.

Lightning Lad, one of the Legion's founding members, was killed in Adventure Comics #304 (January 1963) and revived in issue #312.

Following this was a run as a Dollar Comic format giant-sized book (issues #459–466),[27] including such features as the resolution of Return of the New Gods (cancelled in July–August 1978), "Deadman", and the "Justice Society of America".

Jimmy Olsen continues to delve into the mystery surrounding the American government's safeguards against the new Kryptonian population.

[32] The main creative team of Geoff Johns and Francis Manapul debuted in a backup story in Adventure Comics #0 (April 2009).

The revived ongoing title Adventure Comics features Conner as the headlining character for the first six issues in the story arc entitled, "Superboy: The Boy of Steel".

The same team was to create a ten-part, ten-page "Atom" co-feature in Adventure Comics, but DC ended all its second features and reduced its titles to twenty pages of story.