Two other routes to Apulia, the Via Aemilia in Hirpinis [it] and Via Aurelia Aeclanensis [it], diverged nearby, leading through Aequum Tuticum to Luceria and through Trivicum to Herdoniae respectively.

The road from Aeclanum to Abellinum (modern Atripalda, near Avellino) may also follow an ancient line.

With the Lombard invasion of Italy, in the 6th century AD, it was annexed to the Duchy of Benevento, but was captured and destroyed by Eastern Roman forces under Constans II in 663 and never recovered, being reduced to a small hamlet known as Quintodecimo, a name that referred to its distance of 15 Roman miles from Benevento.

[2][3] Aeclanum became a Christian episcopal see, whose best known bishop was Julian of Eclanum, who was consecrated by Pope Innocent I in about 417.

It has been thought that the diocese was united to that of Frequentium as early as the 5th century, but there is mention of Quintodecimo as a suffragan see of Benevento in 969 and 1058.