On 4 November 2010, the ATR 72 operating the route crashed in the central Cuban province of Sancti Spíritus, killing all 61 passengers and 7 crew members aboard.

[3] At 17:42, the aircraft crashed near the village of Guasimal in Sancti Spíritus province, some 210 miles (340 km) southeast of Havana, after issuing a distress call.

In the passenger cabin were flight attendants Raciel Echevarría, María Torres, Fara Guillén, Juan Carlos Banderas and Andy César Galano.

The passengers and crew were of the following nationalities: In order to allow access to the crash site, rescue workers had to use bulldozers to plow through thick vegetation.

[4] Argentine President Cristina Fernández de Kirchner sent a plane with relatives of the victims to bring home the bodies.