The airline was launched in 2022, by an ex-consultant of Italy's Ministry of Infrastructure and Transport, Francesco Gaetano Intrieri, who is Aeroitalia's CEO and by the initiative of its investor Marc Bourgade, Executive Chairman.

On 9 July 2022, it started operating scheduled flights from Forlì to domestic destinations as well as Malta and Zakynthos.

The airline planned to operate long-haul flights to the United States and Latin America by 2023,[7] but has since stalled the plan in order to consolidate its domestic and European operations.

In July 2024 the airline announced the opening of a new base in Bacau, Romania.

In December 2024 Aeroitalia Regional was sold again, this time to Sicilian investors.