It operates scheduled services to more than 90 destinations[8] in Mexico, North, South and Central America, the Caribbean, Europe, and Asia.

On 8 May 2017, a joint commercial agreement (JCA), came into effect, whereby the airlines share information, costs, and revenues on all their flights between the United States and Mexico.

[15] The Mexico City-New York route would prove profitable for "Aeronaves" and its North American competitors.

[15] Later in the 1960s, more DC-8s were added and service to Europe was resumed, operated by two de Havilland Comet 4C jet aircraft dry-leased by Aerovías Guest prior to the merger.

In 1970, under a government plan, Mexican domestic airlines were nationalized into an integrated air transport system under the control of Aeronaves de México.

A new color scheme (orange and black) was introduced and the airline changed its name from "Aeronaves de México" to its current, shortened version of Aeroméxico in February 1972.

On 31 August 1986, the company suffered its only fatal accident outside Mexico when Aeroméxico Flight 498, a Douglas DC-9, approaching Los Angeles International Airport was struck by a light aircraft.

In April 1988, the state-owned company was declared bankrupt and grounded for three months because of lack of organization, a fleet with an average of 20 years without a renovation plan and a depredating administration by the Mexican Government.

The airline restarted operations with some of its predecessor's assets, including the headquarters building, maintenance hangar, some aircraft, and some former Aeronaves de Mexico employees.

In December 1994, three weeks after Carlos Salinas de Gortari left the office, the first of several devaluations in the next 18 months started, giving way to the Mexican peso crisis.

On 29 March 2006, Aeroméxico CEO Andrés Conesa announced the inauguration of direct flights between Japan and Mexico City via Tijuana.

This was after the purchase of two Boeing 777-200ERs, making Aeroméxico the third airline in Latin America to fly regularly to Asia, after Varig and the now-defunct VASP.

On 29 June 2006, the International Lease Finance Corporation (ILFC) and Aeroméxico announced that the airline would operate three Boeing 787 Dreamliners.

In early October, a week-long auction was held, with Grupo Financiero Banamex, a unit of Citigroup, competing against the Saba family.

In October 2010, Aeroméxico's largest competitor, Mexicana de Aviacion, filed for bankruptcy and was placed in administration.

In 2011, Delta Air Lines and Aeroméxico signed an enhanced commercial alliance, building on an original agreement from 1994.

[24][25] The airline took delivery of its first Boeing 787-8 Dreamliner (sourced from the ILFC order book) in early August 2013 and officially launched commercial service on 1 October 2013.

This particular frame, registered XA-ADL, is named after and painted in a unique commemorating Quetzalcoatl, a major figure in Aztec culture of pre-Hispanic Mexico, as the result of a "Design in the Air" competition hosted by the airline inviting students at select universities in Mexico to submit a potential design to be painted on the airframe.

[32] On July 1, 2021, shareholder Delta Air Lines announced it would purchase $185 million of the Mexican airline's Chapter 11 debt.

[42][non-primary source needed] In July 2016, the airline launched a completely new website and new check-in kiosks at Mexico City Airport.

[44] In August 2017, the company became the Mexico launch customers of digital agency MediaMonks and together, they released a new mobile app.

Aeroméxico falsely claimed that Cayetano did not have the required vaccines, leading to accusations that he was instead prevented from flying to his indigenous ethnicity.

[49] A significant number of complaints emerged in August 2022 after a video of indigenous family being removed from a flight was shared on social media.

[50] In September 2016, Aeroméxico became the first airline in the Americas to launch a chatbot, that enables customers to search, track and book flights interacting with a virtual assistant on Facebook Messenger.

[53][54][55][56] In February 2018, the company announced development of further features together with its partner Yalochat, such as purchase confirmation and flight notifications via WhatsApp, and deepening the artificial intelligence used on its chat platform.

[57] In an attempt to gain more worldwide presence and strengthen its network and to make connections easier and more frequent, Aeroméxico entered new international markets.

[58] The airline launched service to Seoul from Mexico City (with a stop in Monterrey only on the outbound flight) on 1 July 2017.