[1] African Union member states had first considered the idea of establishing a continent wide public health agency in 2013 at an AU Special Summit on HIV, Tuberculosis and Malaria in Abuja Nigeria (July 2013).
In July 2015, the African Union Ministers of Health meeting in Malabo had adopted the Statute of the Africa CDC, which called for fast-tracking the establishment of the institution.
In early April 2020, Director Dr John Nkengasong condemned remarks by two French scientists Professors Jean-Paul Mira and Camille Locht suggesting that a potential tuberculosis vaccine for the coronavirus be test in Africa as "disgusting and racist".
[8] As of June 18, 2020, Africa CDC reported that 52 African Union Member States recorded a number of 267,519 cases, 7197 deaths, and 122,661 recoveries.
[14] In August 2024, Africa CDC declared the 2024 mpox outbreak a Public Health Emergency of Continental Security, as it spread into other African countries from the Democratic Republic of the Congo.
[19] In 2018, at the Beijing Summit of the Forum on China–Africa Cooperation, China announced the construction of the African CDC headquarters as a flagship project in its partnership with Africa, following the success of the AU Conference Center and Office Complex.
[23] On January 11, 2023, Chinese Foreign Minister Qin Gang attended the completion ceremony, announcing that the CDC headquarters would be transferred to the African Union, which will assume full responsibility for its operation and management.