He came up with a plan to test the perceived godly nature of the Spanish: he and Urayoán (cacique of Añasco) sent some of their tribe members to lure a Spaniard by the name of Diego Salcedo into a river and drown him.

[4][2] Agüeybaná II, held Areytos (war dances) or secret meetings with others caciques where he organized a revolt against the Spaniards.

Cristobal de Sotomayor sent a spy, Juan González, to one of the Areitos where he learned of Agüeybaná's plans.

[10] Meanwhile, Guarionex, cacique of Utuado, attacked the village of Sotomayor (present day Aguada) and killed eighty of its inhabitants.

[11] After this, Ponce de León led the Spaniards in a series of offensives against the Tainos that culminated in the Battle of Yagüecas.

[15] A second round of raids erupted in 1513 when Ponce de Leon departed the island to explore Florida.

The settlement of Caparra, the seat of the island government at that time, was sacked and burned by an alliance between Taínos and natives from the northeastern Antilles.