Darshi was born in the city of Birmingham in England, the United Kingdom; to Sikh parents of Indian Punjabi descent.

[2] At the age of 14 she left home and relocated to Calgary, Alberta; which assisted her with the initial steps to pursue a career of acting.

She is best known for her roles in Tru Calling, Dead Zone, The L-Word, and as Laura in the horror film Final Destination 3.

At the 2013 Leo Awards, she won Best Supporting Performance by a Female in a Motion Picture for her role in the feature Crimes of Mike Recket.

In January 2021, she began principal photography on her directorial debut film, titled Donkeyhead, in Regina, Saskatchewan.