The concern of the Spanish government in relation to space issues appears in the 1940s, when the National Institute for Aerospace Technology (INTA) was created.

From March 2023 to December 2023, Miguel Belló Mora, the government commissioner for aerospace projects of the Ministry of Science served as acting director.

[25] The Spanish prime minister disclosed the newly created state agency to be headquartered outside of the capital, Madrid, pursuant to the wider administrative decentralization plan devised by the government.

[26] The Government of Spain however announced that it would positively assess places located less than an hour away from an international airport, with connections to Brussels and Paris, and preferably to Amsterdam, Rome, Frankfurt, Prague, and Toulouse too, cited as the most frequent destinations for work trips among agency staff members.

[29] On 5 December 2022, the Government of Spain, via its spokesperson Isabel Rodríguez, disclosed the city of Seville as the location for the headquarters of the agency,[1] tentatively intended to be operational in early 2023.