[4] Agent 47 is introduced in Hitman: Codename 47 (2000) as a mysterious patient of a sanatorium in Romania who escapes and is subsequently recruited by the International Contract Agency (ICA) as an assassin.

Over the course of the game, 47 travels to Hong Kong, Colombia, Budapest, and Rotterdam to eliminate four seemingly unrelated targets.

At the game's climax, 47 comes face-to-face with his creator and final genetic donor, Professor Ort-Meyer, who unleashes an army of clones dubbed "No.

[5] In the sequel Hitman 2: Silent Assassin (2002), 47 has retired from his career as a contract killer and is leading a simple life as a gardener at a Sicilian church, trying to reconcile with his troubled past.

Over the course of the game, 47 uncovers a conspiracy involving the sale of a nuclear warhead, masterminded by Sergei Zavorotko, the brother of one of 47's genetic donors.

[7] This leads into the events of Hitman: Blood Money (2006), where 47 and his handler, Diana Burnwood, attempt to stop the Franchise from purging the ICA and acquiring the cloning technology that created 47.

After the ICA is wiped out with the exception of 47 and Diana, the former fakes his death and eliminates the Franchise's leaders who come to attend his funeral.

It is then revealed that Travis was acting without his superiors' knowledge, allowing 47 and Diana to resume working for the ICA while the latter looks after Victoria.

[10] 47 eventually discovers the Shadow Client's identity to be Lucas Grey, formerly known as Subject 6, a fellow clone created by Ort-Meyer and his childhood best friend.

From November 2017 to June 2018, Dynamite Entertainment published a six-issue comic book miniseries titled Agent 47: Birth of the Hitman.

[28][29] Complex ranked him as the 5th "best assassin and hitman in video games", noting him as the "original contract killer", while also praising his outfit as "stylish".

[34] In 2024, a poll conducted by BAFTA with around 4,000 respondents named Agent 47 as the third most iconic video-game character of all time, only behind Lara Croft and Mario.