In January 1945, three representatives of the major political forces of the Italian Resistance, Giuseppe Liverani, managing director of Il Popolo (The People), Primo Parrini, managing director of Avanti!, and Amerigo Terenzi, CEO of L'Unità, advanced the possibility to organize a news agency as a cooperative of newspapers, not controlled by the government nor private groups, replacing the work of the Agenzia Stefani, moved to Milan to meet the information needs of the Italian Social Republic.

[2] Some antifascist newspapers immediately adhered, and a makeshift headquarters was set up in Rome, at 15 Moretto Street, unofficially entrusting the direction of former NNU director Renato Mieli.

On 26 August 2014 a five-year partnership agreement (2015–2020) was signed between AP and ANSA for photos, text and video.

ANSA multimedia production is distributed on all the digital platforms (web, TV, satellite, cellphones).

"The ANSAmed package consists of a news stream of about 200 stories and reports per day, in English, Italian and Arabic languages.