Aging-associated diseases

[5] Strategies for engineered negligible senescence (SENS) is an emerging research strategy that aims to repair "root causes" for age-related illness and degeneration, as well as develop medical procedures to periodically repair all such damage in the human body, thereby maintaining a youth-like state indefinitely.

[10] On the basis of extensive research, DNA damage has emerged a major culprit in cancer and numerous other diseases related to ageing.

[11] DNA damage can initiate the development of cancer or other aging related diseases depending on several factors.

[11] Age-related macular degeneration (AMD) is a disease that affects the eyes and can lead to vision loss through break down of the central part of the retina called the macula.

Wet AMD commonly is caused by blood vessels near the retina that lead to swelling of the macula.

[14] These deposits are shown to be neurotoxic and cause cognitive impairment due to their initiation of destructive biochemical pathways.

[15] Atherosclerosis is categorized as an aging disease and is brought about by vascular remodeling, the accumulation of plaque, and the loss of arterial elasticity.

[18] An enlarged prostate can result in incomplete or complete blockage of the bladder and interferes with a man's ability to urinate properly.

"[23] Some of the association between aging and cancer is attributed to immunosenescence,[24] errors accumulated in DNA over a lifetime[25] and age-related changes in the endocrine system.

Studies in animal models show that clearance of senescent cells improves multiple age related endocrine disorders.

By the age of 85 years, ~70% of women and 30% of men have a osteoporosis defined as a bone density less than or equal to 2.5 standard deviations lower than young adults.

The prevalence of the metabolic syndrome increases with age reaching close to 50% of people over 60 years old in the USA.