[3][4][5] Aguila Saleh Issa was born on 11 January 1944, in the town of Al Qubbah, Libya.

Following the 2014 Libyan parliamentary election, Aguila Saleh Issa was elected as Parliament Speaker but was forced to flee to Tobruk along with the rest of the Libyan House of Representatives after Tripoli was seized by militias.

[6] On 20 February 2015, Aguila Saleh Issa's residence was the target of bombing by ISIL militants in the town of Al Qubbah.

ISIL said that the attacks were carried out in retaliation for the 2015 Egyptian military intervention in Libya.

[7] On 20 September 2021, Aguila Saleh Issa announced his intention to temporarily withdraw from parliament in order to run as a candidate for president in the 2021 Libyan general election.