He then spent several years in Mexico's Liga MX, winning league titles with Santos Laguna and Club América, before joining Porto in 2019.

That year, he relegated Mauricio Caranta to the bench and established himself as first-choice goalkeeper, playing in most of Lanús' games of the Apertura tournament.

[4] In December 2014, Marchesín, along with Lanús teammate Diego González, was sold to Mexican side Santos Laguna as a replacement for retiring goalkeeper Oswaldo Sánchez.

[11] He made his debut on 7 August in the first leg of the third qualifying round of the UEFA Champions League away to FC Krasnodar in Russia, making a late save from Rémy Cabella.

[18] Five days later, he was one of four players sent off in a melee at the end of a 2–2 draw with Sporting CP, and was handed a two-game suspension;[19] on 7 December he was also dismissed without playing in a similar event against Atlético Madrid in the Champions League group stage.

[21] On 30 July, days before leaving the club, he played in the 2022 Supertaça Cândido de Oliveira win over the same opposition due to Costa's suspension.

[23] He made his debut 11 days later as the season began with a 2–2 home draw against RCD Espanyol, conceding the equaliser from Joselu's penalty in the seventh minute of added time.

[28] In September 2014, Marchesín received his first call-up in more than three years when Gerardo Martino called him up for the friendly matches against Brazil and Hong Kong, playing against the latter and earning his second cap.

[30] On 15 September 2017, Marchesín received his first call-up under Jorge Sampaoli for the 2018 FIFA World Cup Qualification matches against Peru and Ecuador on 2 and 5 October.