Murillo was signed by the Arizona Diamondbacks as an undrafted free agent in 2002 for the baseball legend Jack Pierce.

At the time, Murillo had a career .275/.344/.399 batting line with 36 home runs and 236 RBI in 514 minor league games.

After his release, Murillo signed with the Tohoku Rakuten Golden Eagles of Nippon Professional Baseball.

[6] On September 27, 2021, Murillo, along with IF Amadeo Zazueta and P Nick Struck, were traded to the Toros de Tijuana of the Mexican League.

[7] On December 30, 2022, Murillo was traded to the Rieleros de Aguascalientes of the Mexican League in exchange for IF Marc Flores.

[11] However, on November 8, Murillo was traded to the Tigres de Quintana Roo in exchange for Javier Erro.