Villagers of Kisoga recall how she used to be carried on a bicycle by a brother to school, about 14 kilometres (8.7 mi) from their home, daily.

She undertook an undergraduate student research project, "Medicinal Plants As Tourism Potential: Case Study of Uganda Wildlife Educational Center (UWEC)", which was supervised by Professor J.

[3][4] In 2003, following her graduation from Makerere, she worked as a tourism officer with Pearl of Africa Tours and Travel Limited.

Beginning in 2005, she served on the board of directors of Jordan Laboratories Limited, a distributor of photographic and printing equipment.

In 2010, she joined active elective politics by contesting the Kayunga District Women's Parliamentary Constituency.

[3] In a cabinet reshuffle on 15 August 2012, she was appointed as State Minister for Lands,[5] replacing Sarah Opendi Achieng.

[1] On 24 March 2019, Nantaba was involved in an incident that led to an innocent person being handcuffed and shot dead by Ugandan police.