[14] In October 2018, Markram was named in Paarl Rocks' squad for the first edition of the Mzansi Super League T20 tournament.

[15][16] In March 2019, Markram signed for Hampshire County Cricket Club as their overseas player for the first part of the season.

[17] Later the same month, Markram scored 127 runs in the final of the 2018–19 Momentum One Day Cup, to help Titans win the tournament.

[21] On 11 September 2021, Markram was included in the Punjab Kings squad for the second phase of the 2021 Indian Premier League (IPL) in the UAE.

[30] In October 2017, Markram was added to South Africa's One Day International (ODI) squad ahead of the third match against Bangladesh, replacing Hashim Amla.

[33] In February 2018, South Africa's captain Faf du Plessis was ruled out of the last five ODIs and the Twenty20 International (T20I) series against India due to a finger injury.

[39][40] In August 2018, Markram was named in South Africa's Twenty20 International (T20I) squad for the one-off match against Sri Lanka, but he did not play in the fixture.

[46] Markram struggled in the first two matches of this series, bagging a pair in the second Test, before being ruled out of the third due to a self-inflicted wrist injury.

[58][59] In March 2023, he was appointed as the captain of South Africa cricket team in T20Is, ahead of their home series against the West Indies.

[60] In October 2023 in a match against Sri Lanka, Markram scored the then fastest century in a men's Cricket World Cup, reaching the milestone in 49 deliveries, a record later broken during the tournament by Australian batter Glenn Maxwell.