In 2010, Sharon Zupancic won a Gemini Award for her work on the season-seven episode, "Lockerbie Disaster", that depicts the bombing of Pan Am Flight 103 in 1988.

A University of New South Wales senior lecturer, Raymond Lewis, conducted a study on teaching strategy loosely based on the series.

[3] The series features re-enactments, interviews (from survivors if there are any, or from people involved in the investigation), eyewitness testimony, computer-generated imagery, and in nearly all of the episodes, voice-actor readings of cockpit voice recorder (CVR) transcripts to reconstruct the sequence of events for the audience.

The responses and reactions of the passengers, crews, and air traffic control personnel leading up to the eventual crash or emergency landing are then recreated.

Scenes in the cockpit and air traffic control centres are recreated using the transcript obtained from the CVR of the aircraft and other recordings made at the time.

Starting in 2021 and continuing to this day, the Wonder and On the Move YouTube channels (owned by Little Dot Studios, a subsidiary of All3Media[11]) uploaded the first nine seasons of Mayday and the Crash of the Century special with the episodes in their full uncut versions and are available in all countries, with the exception of the United Kingdom, where they are geoblocked.

[4] Franck Tabouring from DVD Verdict said, "It's a well-produced show with plenty of compelling information about tragic accidents, telling how some people survived and others didn't.