It operated daily flights to Honolulu, Hawaii, as well as international services to Asia, Micronesia and Australia from its hub at Antonio B.

During its final years, the airline, a Delaware corporation,[5] was headquartered in the old terminal building at Won Pat International Airport in Tamuning, Guam.

Additionally, the plane had to carry spare parts and a mechanic, as well as open-water survival gear and (beginning in 1975) onboard doppler radar, then a rarity.

[citation needed] The airline also operated Boeing 727-100 Combi aircraft models which were capable of transporting freight pallets on the main deck of the jetliner just aft of the cockpit in addition to passengers seated in the rear coach compartment.

[11] William H. Stewart of the Saipan Tribune stated that the airline's foundation "in particular" "was probably the single most important factor in the future development of what were once remote and isolated islands in the Pacific."

Stewart added that the jets "distorted the traveler's impression of time and distance and brought the islands closer to major market areas in Asia.

"[citation needed] Eventually, Continental owned 100% of Air Mike, which at one point provided the only scheduled service directly between Guam and any point in the 50 United States (namely, to/from Honolulu, Hawaii) although other airlines, notably Pan Am, Braniff International and South Pacific Island Airways, had attempted to provide nonstop service between Guam and Honolulu.

[16][17] Since May 1987, the company had the contract to provide passenger and cargo service from Honolulu and Guam to the states of Kosrae, Pohnpei, Chuuk and Yap.

[19] As time passed, the airline's Saipan traffic decreased due to the 1986 breakup of the Trust Territory of the Pacific Islands, which was subdivided into smaller political units.

Soon afterward, Continental Micronesia eliminated most jet services to Saipan in favor of Cape Air's smaller-sized aircraft and increased frequency.

Thirty percent of the airline's business came from its 4,300-mile island-hopper route, which began in Honolulu, made five stops and ended—14 hours and 10 minutes later—in Hagatna, Guam's capital city.

[26] However, on June 12, 2008, Continental's announcement of cuts of services, routes and destinations due to high fuel prices[27][28] included termination of flights to Hong Kong (which has since resumed) and Bali.

Before the flight's cancellation, the flight also served medical referrals from the Commonwealth of the Northern Mariana Islands to Manila and non-USA visa alien contract workers who were unable to transit to their final destinations via Guam; the author opined that the alien workers “particularly were Air Micronesia’s captive audience.”[13] With only Continental Connection/Cape Air services left, Continental closed its Saipan city ticket office on the same day.

[33] Due to small island populations and the corresponding amount of passenger traffic, many of Continental Micronesia's routes were flown less than daily (some as infrequent as twice weekly).