She completed her training at the Patricia Reyes Spíndola school and joined the CNA [es] theatre company.

[3] At age 40, she received critical and public acclaim for her role as Esther in the comedy-drama series Perfect Life (2019–2021).

[2] She won the Special Performance Prize at the 2019 Canneseries alongside co-stars Leticia Dolera and Celia Freijeiro.

Her recent films include Crazy About Her (2021), More the Merrier (2021), On the Fringe (2022), Tomorrow Is Today (2022), and The Red Virgin (2024).

[3][7][1][8][9] For her role playing a domestic servant in La Virgen Roja,[10] Villagrán was nominated for the Goya Award for Best Supporting Actress.