Aizenay (French pronunciation: [ɛz(ə)nɛ]) is a commune in the Vendée department in the Pays de la Loire region in western France.

On 27 March 1944, an American B-17 named "Big Red" crashed at the edge of the Aizenay in the woodland, killing 4 people.

The pilot died of cancer in the 1990s, but his widow returned to see Mme Idais (by then aged 80) to present her with a copy of the book, translated into French.

The commune has several plastics industries such as Cougnaud SA Atlantique Menuiserie, and Lapeyre-Saint-Gobain and businesses making textiles and footwear.

The microwave firm Brandt also operates in the commune, as do several small mills and various agro-food companies.

"Le Fougerais" in Aizenay, a gourmet restaurant listed in the Michelin guide, closed in 2005.

This church with its colorful stained glass, characteristic of the early twentieth century is a fine example of neo-Gothic architecture.

When restoration work began on the church in late 2005, workers were surprised to discover, beneath the floor, several sarcophagi and basements.