She began her career starring in the TV One sitcom The Rickey Smiley Show (2012–2014), and later played Teenage Cookie Lyon in the Fox musical drama series, Empire (2016–2019).

She made her film debut appearing opposite Robin Givens in the 2014 drama Unspoken Words, and later had roles in My First Love (2015), Bad Girl (2016) and Something Like Summer (2017).

In 2018, she played Young Melinda Moore in the psychological thriller film, Acrimony also starring Taraji P.

From 2017 to 2018, Alexus starred as Sheri Holland in the Netflix teen drama series, 13 Reasons Why.

[7] In 2023, Alexus went to star with her BMF co-star Da'Vinchi in Real Love and Strength of a Woman, the two Lifetime movies that were inspired by two of Mary J. Blige's songs.