He was educated at the Medical School of Geneva, whereupon graduation worked at the Pasteur Institute in Paris and prepared a doctoral thesis on ‘‘Long Lasting Cerebrospinal Meningitis’.

He followed in the footsteps of his two elder brothers and entered the Military High School of Medicine after completing his secondary education.

In those years, the Military College of Medicine was known for harboring an environment that opposed the oppressive government of Sultan Abdulhamit and was a place of assembly for those who supported the idea of a national parliament.

During this process, Özden decided to flee to Switzerland in October 1896 and began his education at the Geneva Faculty of Medicine.

[3] Akil Muhtar frequently traveled to France to take lectures from renowned medicine professors in Parisian hospitals such as Georges-Fernand Widal, Anatole Chauffard, and Joseph Jules Dejerine.

In 1914, when Tevfik Vacit Pasha was dismissed from the Haydarpasa Faculty of Medicine staff, Akil Muhtar was appointed to the post as the professor.

Amidst the occupation of Istanbul by the Allied forces, the Faculty of Medicine implemented a successful policy to prevent them from closing.

[5] From 1908 to August 1943, Akil Muhtar Özden worked as a pharmacology professor for 37 years and retired due to old age.

The onset of his disease was somewhat hidden and slowly progressed, he self-diagnosed himself with “mediastinal lymphoma” and even determined the treatment method himself.

Nina was a colleague of Akil Muhtar and earned her title of doctor of medicine in 1908, shortly before marrying Özden.

Working as a gynecologist in Istanbul, she had little luck in building a career and had consultations with her husband's close colleague, Besim Ömer Akalın for future opportunities.

[5] According to Prof. Dr. Fahrettin Kerim Gökay, Akil Muhtar Özden was “spiritually conservative” and was against the admission of women into medical school at the time he was dean.

He had observed that when touched by a needle, the superficial muscles under and around the skin at the stimulated site contracted and that a general backward pull was noticed.

Akil Muhtar showed with these studies that the amount of oxy-santonin excreted is different in liver patients and healthy people.

His book, "Ethics in Terms of Science", which is considered to be his most valuable work in the paramedical field, is 200 pages long.