[1] He attended the Lycée du Parc des Loges (senior high school) in Évry-Courcouronnes, in the southern suburbs of Paris, France, in the 1990s.
[2] From a young age he had admired his great-uncle Abder Isker, the first Algerian director whose work was screened on French television, and the 1976 film Taxi Driver by Martin Scorsese impressed him.
[1] After entering the industry "through the back door" as an actor, starring in a number of short films and telemovies between 2000 and 2009, Isker was offered an opportunity to work as assistant director on the 2001 TV series P.J.
[1] In the 2013 short film J'mange pas de porc (I Don't Eat Pork), he explores his cultural identity, as a Muslim with Algerian roots in France.
[1] In 2017, Isker directed the television series Ben for France Télévisions, with filming taking place in and around the city of Nantes.
[15] In 2024, Tout le monde ment 2 (Everyone lies 2), directed by Isker and starring Vincent Elbaz, was released on France 2.