Al-Qisa (Arabic: القيسا, also spelled Qaysa) is a town in southern Syria, administratively part of the Rif Dimashq Governorate, located southeast of Damascus.

Nearby localities include Harran al-Awamid to the south, Otaybah to the east, al-Abadah to the northeast, al-Jarba to the north, al-Qasimiyah to the northwest, al-Bilaliyah and Deir Salman to the west and al-Ahmadiyah to the southwest.

According to the Syria Central Bureau of Statistics (CBS), al-Qisa had a population of 4,151 in the 2004 census.

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