The highway passes Colonial Brookwood Village, one of the larger shopping malls in the Birmingham metro area and then enters Homewood, whereupon Shades Creek Parkway intersects US 31 (Montgomery Parkway; internally designated as SR 3) at a cloverleaf interchange and the name of the road changes to Lakeshore Drive.

SR 149 closely parallels I-65 for approximately 4 miles (6.4 km) until it approaches the campus of the University of Alabama at Birmingham (UAB).

Bartow Arena, home of the UAB Blazers basketball teams, is located less than 0.25 miles (0.40 km) north of SR 149.

In addition, Regions Field, the home of the Birmingham Barons minor league baseball team is less than 1 mile (1.6 km) north of the highway.

East of the UAB campus and the hospitals, SR 149 continues approximately 0.75 miles (1.21 km) until it reaches its northern terminus at a folded-diamond interchange with US 31/US 280 (Elton B. Stephens Expressway).