SR 41 is a continuation of Florida State Road 87, leading into Alabama from the Gulf coast beaches and Milton.

SR 41 begins its route along a two-lane road south of the small town of Dixonville.

Northbound SR 41 and southbound US 29 share a brief wrong-way concurrency as they head into Brewton.

Just after entering Conecuh County, SR 41 intersects I-65, offering motorists a direct route from the Florida Panhandle to Montgomery and Birmingham.

From there, the highway turns slightly to the northeast until it reaches its terminus east of Selma, at SR 14.