Beginning at Opp, SR 52 assumes a southeastward trajectory as it heads towards Samson in western Geneva County.

At Samson, the highway briefly turns to the east before resuming its southeastward trajectory as it approaches the town of Geneva.

It travels through Hartford, the birthplace of Baseball Hall of Fame member Early Wynn, then continues through Slocomb as it heads towards Dothan, the largest city of Alabama’s Wiregrass Region.

Highways are concurrent with SR 210 (Ross Clark Circle), a circumferential bypass of Dothan.

Media related to Alabama State Route 52 at Wikimedia Commons