The basin is located mainly in eastern Alabama, but also goes includes a small part of Georgia.
This area is classified as a sub-region by the USGS hydrological code system.
Tallapoosa waterbody impairments include mercury due to atmospheric deposition, organic enrichment, siltation, and pathogen pollution due to fecal contamination.
[1] The basin holds many endangered species including the Southern clubshell, and Finelined pocketbook.
Fish species found in the Tallapoosa Basin include the lipstick darter, speckled darter, Tallapoosa darter, stippled studfish, Tallapoosa shiner, largemouth bass, redeye bass, and Alabama spotted bass.