Although this opening is rarely used, Ljubojević (as Black) played against it at Groningen in 1970.
Alapin's Opening is offbeat, but perfectly playable for White.
It is mainly used to avoid highly theoretical lines such as the Ruy Lopez, or to surprise the opponent.
First, the development of White's light-square bishop, and also of his queen, is blocked, and will require another move of the knight or another pawn move, both of which go against the opening principle to develop the minor pieces quickly.
Second, the knight on e2, although flexible, has no control over Black's half of the centre, and will need to be moved again to become more useful.