Predators include birds of prey (such as the snowy owl), lynx, mustelids and wolves, among other animals, as well as humans (typically hunted for food).

It has also been reported that they utilize their feet for defense against predators, notably birds of prey, which attack from overhead.

[3][5] Alaskan hares are known to be carriers of Francisella tularensis, a bacterium that causes an infectious disease known as tularemia, which can be transmitted to pets and humans.

[6] The Alaskan hare is mostly solitary, and the species usually only congregates in groups during mating season in April and May.

They are most commonly found in upland tundra or in rocky or brushy areas which provide camouflage and protection from predators.

[1][4] They are herbivores, eating a variety of foliage and fruits, with foraging taking place primarily at dawn and dusk.