Albert Webb Jefferis (December 7, 1868 – September 14, 1942) was an American Republican Party politician.

He ran unsuccessfully for the United States Senate in 1922 against Robert Beecher Howell.

He was elected a delegate at large to the 1924 Republican National Convention.

He was also the manager of the Coolidge-Dawes automobile caravan from Plymouth, Vermont, to Bellingham, Washington.

He resumed his practice of law in Omaha, trying once more unsuccessfully candidate for United States Senator in 1940.