Alexander C. Rutherford (1905–1910), Arthur L. Sifton (1910–1917) and Charles Stewart (1917–1921) led Liberal governments, until the party was swept from office in the 1921 election by the United Farmers of Alberta.

When Premier Charles Stewart resigned as leader after his government's defeat at the hands of the United Farmers of Alberta in the 1921 election, John R. Boyle, a former Attorney-General, led the legislative caucus until he was appointed to the judiciary in 1924, and Charles R. Mitchell, also a former cabinet minister succeeded him.

John C. Bowen acted in the interim until a party convention chose Joseph Tweed Shaw, a former independent left-wing M.P.

After the defeat of old line parties by Social Credit in the 1935 Alberta general election, the coalition idea picked up steam.

[3] The Alberta Liberals were tepid to support the Independent Citizens' Association led by John Percy Page.

After Gray resigned the leadership on April 19, 1941, to accept a patronage position the party did not officially replace him as leader until James Prowse in 1947.

Cooperation with the Independents officially came to an end when the federal Camrose riding association passed a motion at a meeting in August 1945 calling on the executive of the provincial Liberal party to reorganize in all Alberta provincial constituencies free of alliances and arrangements with other parties.

Hunter, then mayor of Athabasca, who campaigned aggressively on the creation of a publicly owned electrical power company, with strong environmentalist overtones.

This likely limited any growth by the Alberta New Democrats in the 1963 election, and it established the party with a distinct image and identity separate from the Progressive Conservatives.

In a convention which exposed the deep ideological fault lines within the party, Adrian Douglas Berry, a Calgary alderman, emerged as leader from a highly acrimonious contest.

Peter Lougheed and the Progressive Conservatives presented the attraction of a modern, urban-based party which was decidedly more liberal than the Social Credit government.

The party placed very poorly in a byelection to replace a Liberal MLA who had died, and the party had lost its other two seats when Maccagno resigned to run in the 1968 federal election and then in November 1969, the last remaining Liberal MLA, Bill Dickie, crossed the floor to join Lougheed's Progressive Conservatives, who had rapidly established themselves as a credible government-in-waiting.

Lowery thought he saw some hope in an electoral arrangement with Social Credit, which he believed was showing signs of modernization and rejuvenation under Manning's successor, Harry Strom.

The party's political credibility had been steadily eroding, and with the negotiations with Social Credit, it was not immediately clear that it had any ideological purpose.

It was shut out of the legislature altogether in an election that saw Social Credit defeated after 36 years in power at the hands of Lougheed's Progressive Conservatives.

The Liberals' fortunes improved in the late 1980s and they returned to the Alberta legislature in the 1986 election, when leader Nicholas Taylor led them to win 4 seats and 12% of the popular vote.

The Alberta Liberal Party ran one candidate in the 1989 Senate Election, Bill Code, who finished with 22.5% of the vote.

This enabled the party to displace the New Democrats to become the Official Opposition to the Progressive Conservative government of Ralph Klein.

Although Decore now led the second-largest opposition caucus in the province's history, the result was still seen as a disappointment to some prominent Liberals who felt the party had missed its best chance in over 70 years to form government.

Edmonton Mill Woods MLA Don Massey briefly stood as interim leader until a leadership race was held.

Additionally, in June 2007, Craig Cheffins won in a by-election, making him the fourth Alberta Liberal MLA in Calgary.

Going up against rookie Premier Ed Stelmach, the Alberta Liberals had high hopes of increasing their seat count dramatically, particularly with the supposed discontent with the Tories in Calgary.

In the leadership election of 2017, lawyer and former Calgary-Buffalo candidate David Khan received 54.8% of the votes, defeating one rival to become the permanent Liberal leader, under controversial circumstances.

[12] The August 12, 2022 deadline for nominations for the party's leadership election passed with no candidates signing up to run for the position.