He graduated from the Bocconi University in 1986, where he subsequently became a professor of Innovation Management until 2002.

Between 2012 and 2018 he was the director of the Nuova Accademia di Belle Arti, an Art, Fashion, Design private school in Italy.

From 2005 to 2007 he cooperated with Italian Ministry of Education as senior expert for internationalization, member of the undersecretary Nando Dalla Chiesa's cabinet and member of the Directorate General for internationalization of the research activities.

During his professional activity, he offered technical advises to art, fashion and design schools in over 20 different countries, including Chile, China, Mexico, New Zealand, the UK and the US.

On 1 June 2018 Bonisoli was appointed Minister of Culture and Tourism of the Conte Cabinet.