After leaving school, Breccia worked in a tripe packing plant and in 1938 he got a job for the magazine El Resero, where he wrote articles and drew the covers.

During the 1950s he became an "honorary" member of the "Group of Venice" that consisted of expatriate Italian artists such as Hugo Pratt, Ivo Pavone, Horacio Lalia, Faustinelli and Ongaro.

In 1957 he joined publisher Editorial Frontera, under the direction of Héctor Germán Oesterheld, where he created several Ernie Pike stories.

During the seventies, Breccia makes major graphic innovations in black and white and color with series like Un tal Daneri and Chi ha paura delle fiabe?, written by Carlos Trillo.

Other stories include: Cthulhu Mythos, Buscavidas (text by Carlos Trillo), a Historia grafica del Chile and Perramus, inspired by the work of the poet Juan Sasturain a pamphlet against the dictatorship in Argentina.