As a 15-year-old at the 1980 Summer Olympics in Moscow, Mestre competed in the qualifying heats of the 100-meter and 200-meter freestyle events, but he did not advance.

[1] Three years later, Mestre enjoyed significant success at the 1983 Pan American Games in Caracas.

[2] Married Adriana Vivas, and has two children Alberto and Alfonso Mestre, both competitive swimmers.

[3] He graduated from the University of Florida with a bachelor's degree in exercise and sport science in 1987, and was later inducted in the University of Florida Athletic Hall of Fame as a "Gator Great.

"[4] At the 1984 Summer Olympics in Los Angeles, Mestre again competed in the 100-meter and 200-meter freestyle, advancing to the finals in both events, and finishing sixth and fifth, respectively.