After the Lateran Treaty settled the "Roman Question" and made the Vatican an independent state, di Jorio was chosen by Nogara to run the Vatican Bank, and aided by laws that allowed Nogara to freely buy shares in any company even if its business activities did not align with Catholic Church teaching, the Vatican grew immensely wealthy, buying extensively into such wealthy corporations as General Motors, Standard Oil, General Electric and IBM – as well as Italgas, the major supplier of gas in Italy at the time.

[4] Di Jorio participated in the Second Vatican Council and in the conclave of 1963 that elected Pope Paul VI.

On 4 November 1968, Pope Paul accepted di Jorio's resignation–which he had submitted several times in recent years–as pro-president of the Pontifical Commission for the Vatican City State.

[6] Upon the death of José da Costa Nunes on 29 November 1976, di Jorio became the oldest member of the College of Cardinals.

Pope Paul VI preached the homily at a Mass celebrating the seventieth anniversary of di Jorio's priestly ordination.