He was born on 1 July 1593 in his family manor in Ołyka to Stanisław Pius Radziwiłł and Marianna née Myszka.

Apart from directing his family estate in Ołyka at Volhynia (ordynacja ołycka), he was in charge of foreign policies and internal affairs of the Grand Duchy of Lithuania, as he held the posts Lithuanian Vice-chancellor (since 1619),[2] Grand Chancellor of Lithuania[3] and starosta of Vilnius (since 1623), as well as governor of Kowel, Tuchola, Gniew, Pinskas, Wieluń, Daugpilis, Kobrynas and Šiauliai.

Władysław was lenient towards Protestants and encouraged religious tolerance, while Albrycht was an outspoken opponent of all non-Catholics, sometimes even refusing to stamp documents with his Chancellor's seal granting them rights and privileges.

Just like the other Radziwiłł family members, he was famous for the support given to his relatives: he did not fail to watch over the interests of his Calvinist cousins, despite being renowned for his opposition to the heretics.

Despite being one of the most powerful magnates in the Polish–Lithuanian Commonwealth, both of his marriages (with Regina von Eisenreich in 1619, court lady of Queen Constance and after her death in 1637 with Anna Krystyna Działyńska-Lubomirska in 1638) were childless.