[3][14][19] Three years after a tragedy, engineered by Jin Mu, that led Mu-deok to run wild and kill innocent people, Jang Uk, who returned from the dead as a result of the powerful Ice Stone inside his body, becomes a ruthless hunter of soul shifters and becomes increasingly isolated due to his heartbreak over the death of his love—Mu-deok.

[20] Preparations for the series, as well as program discussion with tvN, started in 2019 under the working title Can This Person Be Translated (이 사람 통역이 되나요; I Saram Tong-yeog-i Doenayo).

It was stated that although Park is a rookie actress, she prepared hard for the series, but felt a lot of pressure about playing the main character of a big project.

[70] Line-up for the lead stars consisting of Lee Jae-wook, Jung So-min, Hwang Min-hyun, Shin Seung-ho, Yoo Jun-sang, Oh Na-ra and Jo Jae-yoon was officially announced by tvN on March 3, 2022.

[75] The tree shown in the fictional place called Danhyanggok is located on the lower reaches of the Geumgang River in Garimseong Fortress, Buyeo County.

[81] Alchemy of Souls ranked second, tied with Our Blues, in streaming for Netflix Korea TV show category from January to December 22, 2022.