[citation needed] Her first stage role was Malcom y su lucha contra los Eunucos, by director Alejandro Bichir, presented at the festival of theater in Málaga, Spain.

[citation needed] After working in Mexican television for several years, Barros was given her first starring role in the 2003 telenovela Mariana de la Noche where she essayed the title character with Jorge Salinas as her leading man.

She teamed up with Camacho and Jones once again in 2010's critically acclaimed Para Volver a Amar by Gómez Fernández and Giselle González, where she portrayed Bárbara Mantilla, the suffering, yet flighty and carefree wife of an abusive alcoholic.

[citation needed] Also in 2010, Alejandra Barros co-starred with Eugenio Derbez in the romantic comedy No Eres Tu, Soy Yo which went on to become one of the highest-grossing films in Mexican cinema history.

[1] A year later, she joined the production of Mapat Lopez Zatarain in La sombra del pasado, giving life to the main antagonist Candela Rivero de Mendoza.