[citation needed] Guzmán began her musical career in 1988 with her first song, Bye Mamá, which she dedicated to her mother.

In the 1990s, she released several of her biggest albums like Eternamente Bella, Flor de Piel, as well as Libre which launched with a signed contract to BMG Ariola.

[7] Guzmán joined Luis Fonsi, Carlos Vives and Wisin as coaches on the Spanish-language version of NBC singing-competition The Voice.

[11] Guzmán was also a featured performer on the American music TV series A Tiny Audience produced by February Entertainment.

[14] In 2022, Guzmán appeared in the premiere episode of the music-TV show ¡LaNoche!, produced by February Entertainment and aired in the US, alongside Paulina Rubio.

The PERRÍSIMAS US TOUR 2022[16] kicked off in April 2022,[17] and included major cities such as Chicago, El Paso,[18] New York, Miami, and Las Vegas, before wrapping up on May 22 in Los Angeles.

Her first public relationship was with Erik Rubin which did not last long due to conflict with Mexican singer Paulina Rubio over him.

[23] She later started a relationship with Pablo Moctezuma, a businessman with whom Guzmán has a daughter, Frida Sofía, born March 1992.

They initially had a great relationship but things ended after she suffered a miscarriage and fell into a deep depression, during which time he also wanted to be part of her work team as well as launching a singing career of his own.

In 2021 Frída Sofía caused a huge scandal by asserting that Guzmán's father Enrique had sexually molested her since she was 5.