In 1960 Misharin graduated from the Mikhail Shchepkin Higher Theatre School, and in 1962 he finished the Advanced Course for Screenwriters and Film Directors at VGIK.
Together they wrote their first dramatic poem A Song of Wind (1959) for the Maly Theatre, as well as other plays such as Hamlet from the Flat № 13 (1961), Winter Ballad (1970), Livelong Day (1973), One Yard Chronicles (1978) and others.
The 1977 family comedy Mustached Nanny directed by Vladimir Grammatikov became one of the Soviet box office leaders.
His most successful solo play was Silver Wedding (1985) which was staged by Oleg Yefremov at the Moscow Art Theatre.
In the meantime he made the much acclaimed science fiction film Solaris that featured Misharin in the episodic role.
Misharin was critical of his friend's decision to leave the country which he called a 'creative mistake' influenced by the overrated expectations of his second wife Larisa Tarkovskaya whom he described as mentally unstable and blamed for manipulating her husband.