The elderate borders Vilijampolė and Centras in the north, Šančiai and Panemunė in the east, Garliava in the south as well as Akademija in the west.

After the final Partition of the Polish-Lithuanian Commonwealth in 1795, Aleksotas, unlike most of Lithuania, became part of Prussia, until 1807 when Napoleon incorporated it into the Duchy of Warsaw.

During November Uprising (1830–1831) the insurgent forces used Aleksota hill as artillery post to attack Kaunas, and eventually took the city.

A popular joke at the time had it that the Aleksotas bridge was the longest in the world, because it took twelve days to cross (i.e. the difference between the Gregorian and Julian calendars).

Its commercial and industrial facilities included grain storage houses, a glass factory, an Aleksotas Funicular Railway, the first bridge across the Nemunas, and the international S. Darius and S. Girėnas airport.