The roots of the college are traced back to the Central Turkey College of Aintab founded between 1874 and 1876 by the American Board of Commissioners and Foreign Missions in the Ottoman Empire to serve the large number of Christian Armenian population in the region.

[1] The students of the Aintab College were largely Armenians -mainly Protestant Armenians-, but non-Armenians also attended.

[4] By 1930, with the efforts of the American benefactor James Lack, a large piece of land of 13 hectares was donated to erect the new buildings of the school in the south-western suburbs of Aleppo.

[5] In its life of more than 150 years the college has helped prepare thousands of young men and women for service to society.

In the secular field its graduates have distinguished themselves as teachers, school administrators, nurses, physicians, surgeons, pharmacists, dentists, writers, merchants, engineers, government officials and a cross-section of the occupations of its alumni.