In fall 2006, Cortini contributed to the Musicians Institute's Recording Artist Program by acting as advisor for one-on-one training with students.

In March 2017, Nine Inch Nails' official Twitter account announced Cortini would be part of the 2017 summer performance lineup,[11] during which his primary instrument was bass.

[12] Cortini joined How To Destroy Angels, a project consisting of Trent Reznor, Atticus Ross, Rob Sheridan and Mariqueen Maandig, as a touring member.

He performs multiple instruments onstage and in addition remixed under his SONOIO moniker their single "The Spaces In-Between", which was used as the show finale for the majority of the tour.

In 2013, Cortini returned to Nine Inch Nails as their touring member, and co-wrote the opening track of Hesitation Marks with Trent Reznor.

The band name SONOIO comes from the Italian phrase "sono io", which means "it's me", as it is a solo project consisting solely of Alessandro Cortini.

In 2010, he contributed electronic production to a song called "Birds of Prey" by pop artist Christina Aguilera, produced by Ladytron.

[20][21] In 2021, Cortini released a patchable analog synth called Strega,[22] Italian for “witch,” an instrument he created in collaboration with Make Noise.